| Year | Location | Disease |
| 1657 | Boston, Massachusetts | Measles |
| 1687 | Boston, Massachusetts | Measles |
| 1690 | New York, New York | Yellow Fever |
| 1713 | Boston, Massachusetts | Measles |
| 1729 | Boston, Massachusetts | Measles |
| 1732-3 | Worldwide | Influenza |
| 1738 | South Carolina | Smallpox |
| 1739-40 | Boston, Massachuetts | Measles |
| 1747 | Connecticut, New York, Pennsylvania, South Carolina | Measles |
| 1759 | North America (occupied by non-Native Americans) | Measles |
| 1761 | North America and West Indies | Influenza |
| 1772 | North America | Measles |
| 1775 | North America (especially New England) | Unknown |
| 1775-6 | Worldwide (one of worst epidemics) | Influenza |
| 1783 | Dover, Delaware (high fatalities) | Bilious Disorder |
| 1788 | Philadelphia, Pennsylvania, and New York, New York | Measles |
| 1793 | Vermont (putrid fever) | Influenza; Fever |
| 1793 | Virginia (killed 500 in 5 counties in 4 weeks) | Influezna |
| 1793 | Philadelphia, Pennsylvania (one of the worst) | Yellow Fever |
| 1793 | Harrisburg, Pennsylvania | Unknown |
| 1793 | Middletown, Pennsylvania | Unknown |
| 1794 | Philadelphia, Pennsylvania | Yellow Fever |
| 1796-7 | Philadelphia, Pennsylvania | Yellow Fever |
| 1798 | Philadelphia, Pennsylvania (one of the worst) | Yellow Fever |
| 1803 | New York | Yellow Fever |
| 1820-3 | United States (Started in Schuylkill River area) | Fever |
| 1831-2 | United States (brought by English immigrants) | Asiatic Cholera |
| 1832 | New York City and other major cities | Cholera |
| 1833 | Columbus, Ohio | Cholera |
| 1834 | New York, New York | Cholera |
| 1837 | Philadelphia, Pennsylvania | Typhus |
| 1841 | United States, especially in the South | Yellow Fever |
| 1847 | New Orleans, Louisana | Yellow Fever |
| 1847-8 | Worldwide | Influenza |
| 1848-9 | North America | Cholera |
| 1849 | New York, New York | Cholera |
| 1850 | United States | Yellow Fever |
| 1850-1 | North America | Influenza |
| 1851 | Coles Co., Illinois; Great Plains; Missouri | Cholera |
| 1852 | United States (8,000 died in New Orleans that summer) | Yellow Fever |
| 1855 | United States | Yellow Fever |
| 1857-9 | Worldwide (major outbreak) | Influenza |
| 1860-1 | Pennsylvania | Smallpox |
| 1865-73 | Philadelphia, Pennsylvania; New York, New York, Boston, Massachusetts; and New Orleans, Louisana | Smallpox |
|
Baltimore, Maryland; Memphis, Tennessee; Washington,
D.C. (also Typhus, Typhoid, Scarlet Fever, and Yellow Fever) |
Cholera | |
| 1873-5 | North America and Europe | Influenza |
| 1878 | New Orleans, Louisiana | Yellow Fever |
| 1885 | Plymouth, Pennsylvania | Typhoid |
| 1886 | Jacksonville, Florida | Yellow Fever |
| 1918 | Worldwide (major outbreak) | Influenza |